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March 1963

Chromatographic Analysis of Brain Phospholipids

Author Affiliations

From the Department of Pharmacology, Medical College of Virginia.

Arch Neurol. 1963;8(3):340-343. doi:10.1001/archneur.1963.00460030124013

Introduction  Considerable progress has been made in elucidating the chemical composition and structure of brain phospholipids, as summarized in a comprehensive review by Lebaron and Folch1 and by McIlwain.2 Normal values for the lipid content of human cerebral gray and white matter were reported by Brante3 and more recently by Davison and Wajda.4 However, less information is available on the distribution of phospholipids in the various anatomical areas of the brain. Alterations in the phospholipid composition of cortical gray and white matter have been reported by Cumings5 and Lees and Folch-Pi6 in lipidoses and by Davison and Wajda7 in multiple sclerosis cases. The separation and identification of the phospholipid components of various areas of normal and pathological brains may provide useful information of changes occurring in diseases. As in other branches of lipid research, chromatography has proved a valuable analytical tool. After the

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