The present study is a clinical and pathological analysis of 135 cases of spontaneous massive cerebral hemorrhage in which hemodynamic disorders, especially hypertension, constitute the significant etiologic factors. Massive cerebral hemorrhage is defined as those lesions at least 3 cm in largest dimension in the cerebral hemispheres or 1.5 cm in the brain stem, thus coinciding with Russell's definition.12 Hemorrhages associated with injury, blood dyscrasias, and malformations have not been included in the basic study.
Origins of Hemorrhage.—
The hypertensive group formed 60% of a total of 225 autopsy proven, nontraumatic cerebral hemorrhages. Cerebral aneurysm was responsible for 20% and blood dyscrasias for 13%. The various conditions found in the present group of hemorrhages are shown in Table 1.
Onset of the Strokes.—
The onset of cerebral hemorrhage is usually sudden but may be gradual under special circumstances. In two thirds of the cases in this series
MUTLU N, BERRY RG, ALPERS BJ. Massive Cerebral Hemorrhage: Clinical and Pathological Correlations. Arch Neurol. 1963;8(6):644–661. doi:10.1001/archneur.1963.00460060074008
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.