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July 1963

Laboratory Studies After Intrathecal Corticosteroids: Determination of Corticosteroids in Plasma and Cerebrospinal Fluid

Author Affiliations

From the Department of Neurological Surgery, and the Department of Clinical Pathology, The Cleveland Clinic Foundation.
Fellow in the Department of Neurological Surgery (Dr. Sehgal).

Arch Neurol. 1963;9(1):64-68. doi:10.1001/archneur.1963.00460070074007

Introduction  Methylprednisolone acetate* has been administered intrathecally in more than 1,000 patients for the treatment of neurologic disorders1-3 during the last three years. The treatment has proved safe, and the results are encouraging. It has become a standard method of treatment for arachnoiditis resulting from trauma, Pantopaque, or laminectomy. With this new method of administration we thought it expedient to ascertain: first, how long methylprednisolone acetate remains in the cerebrospinal fluid after intrathecal administration; secondly, whether methylprednisolone acetate injected at the lumbar level is dispersed evenly throughout the subarachnoid space, or remains in a higher concentration at the site of injection, by analyzing fluids obtained simultaneously at lumbar and cisternal punctures; thirdly, the duration of action of the steroid as judged by the effect on endogenous secretion of corticosteroids; fourthly, the effect on spinal fluid pressure, protein and cell content of various amounts of methylprednisolone acetate.

Methods, Procedures, and 

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