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July 1963

Central Aromatic Amine Levels and Behavior: I. Conditioned Avoidance Response in Cats, Following Administration of Psychoactive Drugs or Amine Precursors

Author Affiliations

Kinsmen Laboratory of Neurological Research, Faculty of Medicine, The University of British Columbia.

Arch Neurol. 1963;9(1):69-80. doi:10.1001/archneur.1963.00460070079008

Introduction  The significance to behavior of biologically active amines normally present in the mammalian brain has been receiving increased attention by workers in diversified fields in recent years. This trend has been accelerated by the recognition that a number of potent psychotherapeutic agents seem to assert their beneficial effects by influencing these amines in various ways. For example, the tranquillizing agent reserpine is thought to act by depleting the brain of norepinephrine, serotonin, and possibly other amines,3,9 while the psychic energizing monoamine oxidase inhibitors are thought to act by hindering their destruction.4 Phenothiazines are known to block both peripheral and central effects of a number of amines, presumably by competing for receptor sites. Hallucinogenic agents such as lysergic acid diethylamide (LSD-25) and psilocybin also block certain effects of various amines, but many have the additional property of mimicking the actions of other amines.Relationships between hallucinogenic agents, psychoactive

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