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September 1963

Medical Genetics.

Arch Neurol. 1963;9(3):320-321. doi:10.1001/archneur.1963.00460090126019

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This book can only be recommended with strong reservations. It presents a well-balanced account of human genetics. The chemical basis of gene structure and gene action and the chromosomal basis of the transmission of genes from one generation to the next are described briefly. The interaction of genes with their alleles and with other genes or the environment is described and then used to explain how the phenotype is related to the genotype. The significance of consanguinous matings, the concept of gene frequency, and a minimal number of concepts of probability are introduced in an easy manner. An interesting and varied group of clinical examples adds to the strength of this generally well-organized presentation. This book is quite up to date and includes recent work in many areas of human genetics. A bibliography of more than 350 references is given.

Despite many desirable features, this volume has grave defects. The

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