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November 1963

Pathogenesis of Hemorrhagic Infarction of the Brain: II. Protective Effect of Low Molecular Weight Dextran

Author Affiliations

From the Department of Surgery and the Section of Neurology, Department of Medicine, University of Kansas Medical Center.

Arch Neurol. 1963;9(5):473-476. doi:10.1001/archneur.1963.00460110041004

Introduction  In a previous article on the experimental investigation of the pathogenic mechanism of hemorrhagic infarction of the brain1 we were able to demonstrate in dogs that the combination of systemic hypertension and an adequate collateral circulation appeared to be essential in producing hemorrhagic infarction within an ischemic area resulting from surgical occlusion of the middle cerebral artery.A recent report by Cyrus and his collaborators2 concerning the apparent protective effect of intravenous low molecular weight dextran* (LMWD) led us to in vestigate the use of this material under the experimental conditions described for the production of hemorrhagic infarction.

Materials and Method  Fourteen mongrel dogs weighing between 10-14 kg were used in this experiment. Systemic hypertension was induced by making a surgical coarctation of the thoracic aorta 2 cm above the diaphragm, reducing the lumen of the aorta to approximately 20% of normal. Craniotomy was performed two to

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