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December 1963

Studies of Glioma Growth in Mice: II. Immunity After Excision

Author Affiliations

From the Surgery Branch, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health, Education, and Welfare, Bethesda, Md.

Arch Neurol. 1963;9(6):671-676. doi:10.1001/archneur.1963.00460120121013

The poor prognosis associated with malignant brain tumors, even at the present level of technological development, points to the need for a better understanding of the relationships between these tumors and their hosts. To this end, studies of natural and induced immunity to human and animal gliomas have recently been initiated by a number of investigators.1,2,7,8,11-13 The present report, representing one such study, shows that mice can be immunized against transplantable gliomas by the introduction of these tumors and their subsequent surgical removal.

Materials and Methods  Employed in the present study were 570 C57BL/ 6JN female mice weighing 13-16 gm. These animals were housed in groups of 20 or less, they received food pellets and water ad libitum, and they were weighed weekly.Three mouse gliomas were studied.9,17,19 All three had been induced in C57BL mice by intracerebral implantation of methylcholanthrene and had been carried by subcutaneous trocar

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