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January 1964

Neurokinin and Pain-Producing Substance in Congenital Generalized Analgesia

Author Affiliations

Department of Pharmacology of the Faculty of Medicine, University of São Paulo, (Dr. Ramos), and Pedriatric Clinic, Escola Paulista de Medicine, São Paulo, (Dr. Schmidt).

Arch Neurol. 1964;10(1):42-46. doi:10.1001/archneur.1964.00460130046006

Congenital generalized analgesia is a relatively rare entity, since only 69 cases have been described. Dearborn,1 in 1932, was the first to describe such a case: a 54-year-old man without evidence of any mental disturbance who made use of his generalized analgesia by exhibiting himself in theaters.

Congenital general anesthesia is present in the individual from birth, and it may affect more than one member of the family. Tactile and thermal sensibilities are normal, and the only disturbance is the absence of reaction to painful stimulations, deep or superficial. The corneal reflex is absent in many cases. The diagnosis is usually made by the patient's relatives, who observe during the first year of life that the child does not cry when given injections, or when it falls during attempts to crawl or walk. Generally the intelligence is normal or only slightly reduced.

Several hypotheses have been suggested to explain

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