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January 1964

Electrolytes and Fluids in Experimental Focal Leukoencephalopathy

Author Affiliations

From the departments of neurology and pathology (neuropathology), Albert Einstein College of Medicine, New York, and St. Francis Hospital, Jersey City, NJ.

Arch Neurol. 1964;10(1):58-65. doi:10.1001/archneur.1964.00460130062009

Recent morphological and biochemical investigations of cerebral edema indicate that there are several forms of edematous process. These forms depend upon the agent producing the edema and upon whether gray or white matter is involved. Thus, the electron micrographic and chemical findings in gray and white matter in the generalized edema produced by triethyltin intoxication1-3 differ from the ultrastructural and chemical findings in focal edema produced by intracranial masses.4-6 This paper records the changes in the uptake of S35O4, albumin I131, and Na24 in the gray and the white matter of rat brain with a focal inflammatory edema produced by implantation of purified protein derivative (PPD). In PPD-induced edema, electron micrographs show that the fluid accumulates intracellularly in gray matter and extracellularly in white matter.7 The uptake of S35O4 provides an independent measure of extracellular space.8,9 The uptake