While a number of light microscopic investigations have demonstrated nerves within the walls of intracranial vessels,1-3 the nature and importance of this innervation remains conflicting.4 Experiments on cats indicate the presence of vasomotor fibers,5 but the evidence for a neurogenic constrictor effect on human cerebral vessels is meager. Ray and Wolff elicited painful sensations by stimulation of vessels at the base of the brain in man,6 but little is known concerning the receptor mechanism in these or other blood vessels.
Ultrastructural information on vessel innervation is also limited. Pease and Molinari mention but do not illustrate the fine structure of unmyelinated nerves in the adventitia of vessels from the subarachnoid space of the cat.7 Single electron micrographs depicting a group of unmyelinated nerves in the coronary artery of a rabbit8 and a rat9 have been published.
In view of the considerable current interest
DAHL E, NELSON E. Electron Microscopic Observations on Human Intracranial Arteries: II. Innervation. Arch Neurol. 1964;10(2):158–164. doi:10.1001/archneur.1964.00460140044007
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