Since the first work on the use of gamma emitters for the localization of brain tumors,1,2 there has been a surge of activity in the investigation of the role which radioactive isotopes could play in the diagnosis of human brain tumors. Radio-iodinated serum albumin (Risa) was first introduced in 1951.3 Since that time, it has been used extensively, both on a clinical and an investigative level, in the localization of intracranial tumors.Though it has long been known that radioiodinated serum albumin will localize within brain tumors in varying concentrations, it had never been determined at exactly which level the localization of radio-iodinated serum albumin occurred. That is to say, there was no information regarding the exact compartment (intracellular, extracellular, intravascular) of a cerebral or extracerebral tumor in which the radio-iodinated serum albumin localized.It had been assumed that the radioiodinated serum albumin was picked up in
RAIMONDI AJ. Localization of Radio-Iodinated Serum Albumin in Human Glioma: An Electron-Microscopic Study. Arch Neurol. 1964;11(2):173–184. doi:10.1001/archneur.1964.00460200069006
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