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September 1964

Is the Brain "An Immunologically Privileged Site"?1. Studies Based on Intracerebral Tumor Homotransplantation and Isotransplantation to Sensitized Hosts

Author Affiliations

From the Saul R. Kovey Department of Neurology and the Department of Neurological Surgery, Albert Einstein College of Medicine of Yeshiva University.

Arch Neurol. 1964;11(3):248-264. doi:10.1001/archneur.1964.00460210026003

Introduction  The failure of the brain to respond with a typical immune reaction when challenged by intracerebral implantation of nonisologous tissue has intrigued investigators and led to considerable speculation. Medawar1 showed that the brain does not respond with the typical "primary or secondary set reaction" histologically when homologous skin is implanted in the cerebrum. Greene2-4 demonstrated that the brain will accept tumor homotransplants or heterotransplants. These phenomena and the failure to demonstrate lymphatic channels in the brain have led to the concept that the brain is "an immunologically privileged site."The purpose of this report primarily is to present results of some investigations that further examine this concept. However, knowledge of the histologic events which occur when a tumor homotransplant or isotransplant is placed in the brain of the experimental animal may also prove useful in the understanding of the mechanisms by which the human brain reacts to

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