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September 1964

Periodic Diseases.

Arch Neurol. 1964;11(3):336. doi:10.1001/archneur.1964.00460210114014

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Since 1932, Dr. Reimann has been interested in periodic diseases. An interrelationship amongst periodic edema, periodic arthrosis, and periodic purpura had been assumed for nearly a century. To the afore-mentioned illnesses Dr. Reimann has added periodic fever, periodic myelodysplasia, periodic sialadenosis, periodic peritonitis, periodic pancreatosis, periodic paralysis, and periodic psychoses. Periodicity, heredity, autonomic disturbances, long duration, undisturbed development, good general health, and unknown etiology are common to each entity. The author assumes the existence of an innate biorhythm related to the old theory of "biological clocks." In this connection he expresses the belief that episodes of most periodic entities seem to present responses to sudden excitations in the hypothalamic area. The author himself mentions that he has been criticized for grouping disparate maladies on the basis of periodicity only. Such criticism still appears to be justified at least as to grouping of the psychiatric and neurological disorders with the bulk

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