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November 1964

Glioblastoma Multiforme: Present Status

Author Affiliations

From the Department of Surgery, Division of Neurosurgery, University of Kentucky Medical Center.

Arch Neurol. 1964;11(5):562-568. doi:10.1001/archneur.1964.00460230112012

Glioblastoma multiforme is a malignant tumor with a uniformly fatal course. Palliation achieved by conventional radiation and surgical techniques can be measured in terms of months. The urgent need for new avenues of approach prompted a review of current laboratory and clinical investigation relating to glioblastomas.

Tissue Culture and Heterotransplantation Neuroglial tumors have been grown by a variety of tissue culture techniques during the past 30 years. Russell and Bland37 studied 20 gliomas in tissue culture and established the basis for their identification and classification in vitro. Lumsden21 recently published his extensive experience with the astrocytoma-glioblastoma group of tumors and reviewed previous contributions to this subject. He differentiated normal and neoplastic astrocytes in plasma clot preparations by their rate of migration and by the number and branching of their processes. These observations were made in short-term cultures, and not until 1959 did Manuelidis26 report long-term culture of

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