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December 1964

Limbic Nuclei of Thalamus and Connections of Limbic Cortex: VII. Transcallosal Connections of Cerebral Hemisphere With Striatum in Monkey and Man

Author Affiliations

From the Department of Neurology and Warren Anatomical Museum, Harvard Medical School; The Neurological Unit, Boston City Hospital; Montefiore Hospital, Pittsburgh, and the Department of Psychology, University of Pittsburgh.

Arch Neurol. 1964;11(6):571-582. doi:10.1001/archneur.1964.00460240003001

Introduction  Until recently, the existence of connections between the cerebral cortex and the corpus striatum was not generally accepted. Among older writers, Déjerine1 denied them. The historical background of the problem was summarized by Mettler in 1942,2 who concluded that the balance of evidence favored the existence of such connections via the subcallosal bundle of Muratov. Recently corticofugal projection fibers arising from wide fields of cortical origin to the ipsilateral corpus striatum were demonstrated in rat3 and in rabbit.4 In an earlier study in this series,5 evidence was adduced that the fibers of the subcallosal bundle are collateral branches of the ipsilateral and contralateral cingulum, distributed bilaterally, and apparently in about equal proportion to the corpus striatum of each hemisphere. It was shown that the commissural callosal fibers interconnect mainly, the convexities of each cerebral hemisphere (supralimbic cortex, "écorce supérieure" of Cajal) and run