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December 1964

Brain Damage After Intracarotid Infusion Of Methotrexate

Author Affiliations

From the Department of Pathology, General Rose Memorial Hospital, Division of Neurology, U. of Colorado School of Medicine and Neurology Section, Denver VA Hospital.

Arch Neurol. 1964;11(6):618-625. doi:10.1001/archneur.1964.00460240050007

In the past few years there has been great interest in regional chemotherapy for the treatment of various malignant tumors. Drugs used for this purpose have included alkylating agents, such as mechlorethamine hydrochloride (a nitrogen mustard), and antimetabolites, of which methotrexate has been extensively employed. These methods have recently been applied to the management of malignant intracranial neoplasms. To date, there has been little well-documented information on the effects of cancer-inhibiting agents on the human brain. The purpose of this report is to describe and analyze cerebral damage resulting during the course of methotrexate injection into the internal carotid artery.

Report of Case  History.—A 36-year-old white housewife was well until January, 1961 when she noted a small "bruise" on her left arm which, when biopsied, proved to be a "reticulum cell lymphosarcoma" (Fig 1). Treatment with cesium was given. At this time she complained of easy premenstrual bruisability, but

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