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December 1964

Intracranial Aneurysm Rupture, Vasospasm, and Infarction

Author Affiliations

From the Departments of Pathology (Division of Neuropathology) and Radiology, Columbia University, College of Physicians and Surgeons.

Arch Neurol. 1964;11(6):668-680. doi:10.1001/archneur.1964.00460240100013

During a recent study of the relationship between spontaneous rupture of saccular intracranial aneurysms and cerebral infarction, a preliminary comparison with angiographic reports of cerebral vasospasm was made.1 Infarcts were found in the brains of 65% of patients in whose angiograms vasospasm had been noted, while 82% of patients for whom vasospasm had not been reported also had infarcts. These figures suggested that there was no correlation between these two factors. However, since many of these reports were from the early days of cerebral angiography and represented the reading of many radiologists, it was felt that a more thorough study of this relationship was indicated to better assess the role of vasospasm in the production of cerebral infarcts in these patients.

Material and Methods  Eighty-five cerebral angiograms performed on 53 patients after rupture of an intracranial aneurysm were reviewed by one of us (I. K.) with-out prior knowledge

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