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January 1965

Sensory Radicular Neuropathy

Author Affiliations

From the Department of Medicine and Division of Neurology, Duke University Medical Center.

Arch Neurol. 1965;12(1):19-24. doi:10.1001/archneur.1965.00460250023003

Hereditary sensory radicular neuropathy is a rare clinical entity characterized by the familial occurrence of a sensory deficit in the distal lower limbs associated with chronic perforating ulcerations of the feet and progressive destruction of the underlying bones. Patients with this disorder may have deafness, lightning pains in the legs, and sensory involvement of the upper limbs as well. Sporadic forms, usually without deafness and lightning pains, also occur. The pathologic lesions in this illness consist of degeneration of the dorsal root ganglia and dorsal roots and were first described by Denny-Brown in 1951.1 After his classic description, approximately 30 well-documented cases have been reported.2-8 The majority of these have been recorded in the French literature under the name "acropathie ulceromutilante." The present report describes the occurrence of this syndrome in a Negro who also had optic atrophy. To our knowledge all the previously described cases were in

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