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January 1965

Total Cerebral Blood Flow And MetabolismA New Method for the Repeated Serial Measurement of Total Cerbral Blood Flow Using Iodoantipyrine (1131) With a Report of Determination in Normal Human Beings of Blood Flow, Oxygen Consumption, Glucose Utilization and Respiratory Quotient of the Whole Brain

Arch Neurol. 1965;12(1):49-66. doi:10.1001/archneur.1965.00460250053007

The traditional measurement of cerebral blood flow (CBF) by the nitrous oxide method of Kety and Schmidt1 has the two important limitations that flow rates reflect only the average rate over a ten-minute equilibratory period and that the values reflect rates per unit weight of perfused cerebral tissue. The first limitation prevents obtaining quantitative data concerning brain blood flow and metabolism under short-acting stresses and rapidly changing states, while the second may prevent recognition of changes in the total mass of perfused brain.

Wechsler2 and Lewis et al3 have recently employed Kr79 as the inert gas in CBF determinations, and by virtue of the ability to monitor continuously the brain content of γ-emitting Kr79 by external head scintillation detectors were able to measure minute by minute values of CBF over approximately five minutes of a ten-minute period of Kr79 inhalation. This valuable advance in

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