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February 1965

Physiologically Induced Alteration of Sulfate Penetration Into Brain

Author Affiliations

From the Department of Pharmacology and Division of Otolaryngology, University of Chicago.

Arch Neurol. 1965;12(2):128-132. doi:10.1001/archneur.1965.00460260018002

THE MEASUREMENT of local cerebral blood flow using the principles of inert gas exchange between blood and tissue has been described by Kety.1,2 The radioactive inert gas trifluoroidomethane (CF3I131) has been used to map blood flow in the various regions of the cat brain in both the conscious and the anesthetized animal. With CF3I131 the effect of increased functional activity on local blood flow has also been demonstrated. Sokoloff3 showed an increased autoradiographic density in the striate cortex and the lateral geniculate ganglia demonstrating an increased blood flow to these structures after photic stimulation.

The usefulness of the inert gases in the evaluation of blood flow depends upon their free diffusibility from the vascular bed. Thus this characteristic of the gas, which is essential for the measurement of blood flow, makes CF3I131 inadequate as a measure of local changes

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