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March 1965

Human Cerebral Lactate and Pyruvate Extraction: I. Control Subjects

Author Affiliations

From the Department of Neurology, University of Miami School of Medicine.

Arch Neurol. 1965;12(3):246-250. doi:10.1001/archneur.1965.00460270022003

THE PURPOSE of this study was to explore the lactate and pyruvate levels of arterial and cerebral venous blood in normal resting persons and in ill hospitalized patients, with methods and conditions routinely used in our laboratory. These control results would be preliminary to a study of cerebral anoxia or hypoxia. Evaluation of excess lactate production, as described by Huckabee1,2 is possible by calculations from such data.

Excretion of lactate by the resting brain might indicate that some of the glucose taken up by brain is not metabolized beyond the end reaction of anaerobic glycolysis. It has been known from results obtained in several laboratories that the ratio of glucose to oxygen utilization by brain in vivo is not stoichiometric; approximately 6.0 vol% O2 and 10 mg% glucose are representative average values for cerebral oxygen and glucose extraction respectively. The difference between the glucose taken up and

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