ECHO and Coxsackie viruses have been associated with neurologic illnesses with increasing frequency in recent years. Most of the neurologic symptoms and signs have been mild— especially when compared with the effects of the arthropod-borne viruses, and there has consequently been little information available concerning the long-term course of patients with these more benign viral infections. Anderman et al speculated that viral infections may play an etiologic role in the production of epileptogenic scars.1 Our interest in more prolonged evaluation of patients with viral infections, correlating electroencephalographic (EEG) and neurologic signs, resulted in this study.
This report concerns 45 patients with fever and signs suggesting neurologic disease, usually nuchal rigidity plus lethargy or irritability, admitted to the North Carolina Baptist Hospital from September 1960 until October 1963. Thirty-four of these patients had ECHO or Coxsackie virus infections, EEGs, and followup examinations. The 11 patients were rejected because their
SPUDIS EV, CRAMBLETT HG. ECHO 4 Meningoencephalitis. Arch Neurol. 1965;12(4):404–409. doi:10.1001/archneur.1965.00460280074007
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