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August 1965

Attempted Induction of Gliomas Utilizing Simian Virus 40

Author Affiliations

From the Division of Neurosurgery, Duke University Medical Center, Durham, NC.

Arch Neurol. 1965;13(2):149-154. doi:10.1001/archneur.1965.00470020039005

METHOD of producing intracranial neoplasms in rats, rabbits, cats, or dogs would be a very useful adjunct to the study of human brain tumors. These animals are readily available and inexpensive, and such a method could be employed in the preliminary testing of diagnostic and therapeutic techniques, thus avoiding the use of human patients for these purposes.

Spontaneous intracranial neoplasms are uncommon in animals.1-12 Furthermore, although neoplasms originating in tissues outside the nervous system of the host can be transplanted intracerebrally in several species of animals,12-24 the difference between these tumors and primary gliomas limits their value as experimental models.

Primary gliomas can be induced consistently in mice by the intracerebral insertion of carcinogens,12,25,26 and occasionally in rats by the intracerebral insertion12,25,27-32 or oral administration33-35 of similar chemical agents. Also, tumors resembling ependymomas can be induced in hamsters by the intracerebral injection of simian virus

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