SYMPTOMS referable to the central nervous system (CNS) without direct anatomic involvement are common in Hodgkin's disease but actual invasion of the brain is a rarity. Bony deposits at the base of the skull may terminally invade the meninges and base of the brain and this mode of spread has accounted for the bulk of reported cases.1 Kohut2 reported a case with diffuse invasion of the meninges. Most cases reported have therefore consisted of a terminal cerebral phase of an established generalized Hodgkin's disease. Sparling and Adams3 reported the first case of Hodgkin's disease arising in the brain. The present case report is considered of some interest due to its rarity and the fact that the initial manifestations presented in a distinctly unusual manner.
Report of a Case
A 61-year-old white x-ray technician was admitted to the Brooklyn Veterans Administration Hospital in March 1964 with weight
KAUFMAN G. Hodgkin's Disease Involving the Central Nervous System. Arch Neurol. 1965;13(5):555–558. doi:10.1001/archneur.1965.00470050103013
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.