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January 1966

The Protective Effect of Hyperbaric Oxygenation in Cerebral Anoxia

Author Affiliations

From the Cardiovascular Laboratory and Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC.

Arch Neurol. 1966;14(1):15-20. doi:10.1001/archneur.1966.00470070019002

THE INHALATION of oxygen at increased atmospheric pressures greatly increases the alveolar tension of oxygen and produces a marked elevation in arterial blood oxygen tension and content if respiratory gas exchange is efficient. The resultant increase in oxygen delivery to the tissues may prolong functional activity during circulatory arrest and anoxia.

This report presents observations on the protective effects of hyperbaric oxygenation in experimentally induced cerebral anoxia. The function of the cerebral tissues during anoxic stress was monitored by continuous electroencephalographic recording. Anoxia was induced either by inhalation of 100% nitrogen or by circulatory standstill following electrically induced ventricular fibrillation. Studies were made in normothermic and hypothermic animals after inhalation of 100% oxygen at normal and increased atmospheric pressures.

Materials and Methods  Seventeen mongrel dogs, weighing 10 to 20 kg (22 to 44 lb) were studied in a hyperbaric chamber large enough to accommodate the animals and the attendant personnel.