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February 1966

Cerebral Infarcts and the Lesions of Intracranial and Extracranial Atherosclerosis

Author Affiliations

From the departments of pathology, psychiatry, and neurology, Louisiana State University School of Medicine, and the Charity Hospital, New Orleans.

Arch Neurol. 1966;14(2):124-128. doi:10.1001/archneur.1966.00470080008002

A STUDY in which the complete arterial circulation to the human brain and a standard brain dissection by the same observer were available in every one of 204 cases seemed an appropriate one for obtaining more data regarding the role of the intracranial and extracranial circulation in the pathogenesis of cerebral infarcts. Specifically, the complicated lesions of atherosclerosis (thrombi, ulcerations, and hemorrhages in fibrous plaques), stenosis, and calcification were assessed in the intracranial and extracranial arteries, and individual cases were analyzed when cerebral infarction was present.

Materials and Method  The first 204 cases from the New Orleans material of the Cerebrovascular Disease Study of the International Atherosclerosis Project were available for study. These patients were 10 to 69 years of age and chosen by lot without regard to cause of death from the autopsy material of the Louisiana State University unit of Charity Hospital of Louisiana at New

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