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March 1966

Serum Amino Acid Studies in Amyotrophic Lateral Sclerosis: II. Results of Metrecal Arginine Lysine Tolerance Tests in US Caucasians and Guam Chamorros*

Author Affiliations

From the Section of Experimental Neurology, Department of Medicine, University of Kansas Medical Center, Kansas City, Kan and Division of Neurology, University of Missouri School of Medicine, Kansas City General Hospital, Kansas City, Mo.

Arch Neurol. 1966;14(3):305-312. doi:10.1001/archneur.1966.00470090077011

Previously we reported upon the results of arginine tolerance tests carried out in patients with amyotrophic lateral sclerosis (ALS) and hospitalized controls, both groups consisting of Caucasians living in the Kansas City area.1 The levels of arginine were noted to be significantly lower in the patients than in the controls.

Later, because of the extraordinarily high incidence of ALS among the Chamorros on Guam, and because there have been suggestions that the disease there might be different from the sporadic ALS encountered in Caucasian Americans,2 the Metrecal arginine lysine tolerance test (MALTT) was also carried out both on Chamorro patients with ALS and hospitalized controls at the Guam Memorial Hospital, Agana, Guam in March 1964. The present paper describes and discusses our observations in these patients and controls.

Material and Methods  Patients and Controls.—A myelogram was performed on all patients whose disease had been diagnosed as ALS

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