[Skip to Content]
[Skip to Content Landing]
April 1966

Directed Attack Behavior During Hippocampal Seizures

Author Affiliations

From the Department of Psychiatry, School of Medicine, Western Reserve University, Cleveland, and the Department of Physiology, Yale University School of Medicine, New Haven, Conn.

Arch Neurol. 1966;14(4):408-414. doi:10.1001/archneur.1966.00470100064008

IN RECENT years considerable attention has been paid to the electrical and behavioral phenomena associated with seizures or after-discharges induced by electrical and chemical stimulation of the hippocampus and related structures. The possible relevance of such induced seizures to the clinical syndrome of temporal lobe epilepsy has been cited on several grounds including anatomical data, the character and propagation pattern of electrical discharge, and on the basis of correlated behavioral effects. The electrical phenomena of hippocampal seizures, initiated by electrical stimulation in particular, are well established in terms of threshold, patterns of discharge and recovery, pathways of propagation, and unit activity.1-6

In contrast to their physiology, however, the effects of hippocampal seizures have not been clearly determined from the standpoint of their behavioral consequences. Observations concerning the effects of such seizures on behavior are generally consistent on two points. First, the unilateral after-discharge restricted to the hippocampal structures