THE FINDING of intranuclear inclusion bodies in tissues infected by such a virus as herpes simplex was stated to "represent... the presence and growth within the nucleus of the specific virus of the disease" (Goodpasture and Teague, 1923).1 They further concluded that the "presence of the intranuclear inclusion body is prima facie evidence of the local presence of this (herpes febrilis) or a similar virus." Lipschütz (1912)2 had earlier arrived at a similar conclusion, and DeFano (1923)3 provided supporting evidence. Cole and Kuttner (1926)4 further added that intranuclear inclusions in any lesion indicate that the injury is due to an infective agent belonging to the group of filterable viruses.
On the other hand, Cowdry (1934)5 later suggested that the presence of intranuclear inclusions did not necessarily point to a viral etiology, but it could be regarded as a "fingerprint of a special and
ITABASHI HH, BASS DM, McCULLOCH JR. Inclusion Body of Acute Inclusion Encephalitis: An Electron-Microscopic Study in a Case of Suspected Herpes Simplex Encephalitis. Arch Neurol. 1966;14(5):493–505. doi:10.1001/archneur.1966.00470110037005
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