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August 1966

Plasma Lipids in Epileptic Children Treated With the High Fat Diet

Author Affiliations

From the Section on Child Neurology, SN, National Institute of Neurological Diseases and Blindness, Bethesda, Md.

Arch Neurol. 1966;15(2):177-184. doi:10.1001/archneur.1966.00470140067009

THE HIGH fat diet, referred to in the neurological literature as the ketogenic diet, was first introduced by Wilder1 for the treatment of epilepsy. Subsequently, Talbot,2 Wilkins,3 Bridge,4 Livingston,5 Keith,6 and others amply confirmed the beneficial effect of this diet in controlling cerebral seizures. In general, these authors conceded that children under 8 years of age who suffer predominantly from minor attacks show the best results. This was generally attributed to the fact that dietary ketosis is difficult to accomplish in older children and in adults. Based on several large series of patients,4-6 the following empirical generalization is frequently quoted: About 30% of properly selected children with epilepsy will have their seizures controlled while on the diet; an additional 30% will show partial improvement in the frequency of seizures; and in 40% the attacks will remain uninfluenced. Strict adherence to the high

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