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September 1966

Cerebellar Disease in Infectious Mononucleosis

Author Affiliations

From the Division of Hematology, Henry Ford Hospital, Detroit.

Arch Neurol. 1966;15(3):270-274. doi:10.1001/archneur.1966.00470150048008

INFECTIOUS mononucleosis has perplexed the clinician with a myriad of signs, symptoms, and complications. We describe an unusual patient in his presenting form and subsequent course.

The first report of infectious mononucleosis in 1885 by Filatoff1 * classified the disease as a juvenile cervical adenitis, an infectious disease of childhood. The prevalence was felt to be epidemic involving both infants and children. In Pfeiffer's classical description of "Drüsenfieber" in 1889,2 recognition was made of involvement of the liver and spleen. Forty years passed before the numerous complications and confusing forms of the disease began to reach the literature, including skin, hematologic, and serologic manifestations.3-7 Recently, clinicians have become more aware of the complications of the central nervous system (CNS). Most of these have taken the form of meningoencephalitis, isolated peripheral neuropathy, or polyradiculitis.8-10 Our patient was afflicted with a rare neurologic complication: a cerebellitis, which mimicked an

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