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October 1966

Familial Multiple Sclerosis Associated With Narcolepsy

Author Affiliations

From the Neurological Clinic, Karolinska Sjukhuset, Stockholm.

Arch Neurol. 1966;15(4):337-344. doi:10.1001/archneur.1966.00470160003001

THE INVESTIGATIONS of Curtius1 and Mackay2 focused increasing interest on the familial occurrence of multiple sclerosis (MS). Several studies have been reported in recent years.3-7 In large series of multiple sclerosis, the incidence of the familial form has ranged from 3% to 12%.8 The risk of contracting the disease is stated to be more than 15 times greater in a close relative of a patient with MS than in the general population.8 It therefore seems reasonable to presume that hereditary factors are of etiological importance. Myrianthopoulos and Mackay6 suggested that the mode of inheritance is autosomal recessive with reduced penetrance.

Studies of monozygotic twins have, on the other hand, shown low concordance for MS.5,9,10 This has been used as an argument against genetic factors being of any decisive consequence.10

This paper comprises a report of a form of familial MS associated

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