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October 1966

Sjögren's Syndrome and Late-Life Myopathy

Author Affiliations

From the Division of Neurology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC. Dr. Fox was formerly a resident in psychiatry at the University of North Carolina School of Medicine in Chapel Hill. His present address is 2525 Sharon Rd, Charlotte, NC.

Arch Neurol. 1966;15(4):397-398. doi:10.1001/archneur.1966.00470160063008

IN 1933 Henrik Sjögren1 described a syndrome consisting of the triad of keratoconjunctivitis sicca ("dry eyes"), xerostomia ("dry mouth"), and rheumatoid arthritis. Lacrimal or salivary gland enlargement may or may not be present. Two of the three major components are generally considered sufficient for the diagnosis.2 In 1962 Silberberg and Drachman3 reported four cases of late-life myopathy occurring with Sjögren's syndrome. Although one of their patients had a history of arthritic symptoms, examination of that patient disclosed no significant abnormalities of the joints. This report describes a patient who presented with late-life myopathy and was found to have Sjögren's syndrome, including active rheumatoid arthritis. She is thought to represent the first published report of a patient with Sjögren's syndrome who demonstrated both active rheumatoid arthritis and active myopathy.

Report of a Case  A 45-year-old Negro housewife was first admitted to the hospital in 1960 because of

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