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November 1966

Stereotaxic Lesions in Parkinson's Disease: Clinicopathological Correlations

Author Affiliations

From the Division of Neurology, Department of Medicine (Dr. Markham), Division of Neuropathology, Department of Pathology (Dr. Brown), and the Division of Neurosurgery, Department of Surgery (Dr. Rand), UCLA School of Medicine, Los Angeles.

Arch Neurol. 1966;15(5):480-497. doi:10.1001/archneur.1966.00470170034004

THERAPEUTIC stereotaxic lesions in the thalamus and basal ganglia have been made in a variety of movement disorders over the last 15 years. Both before and during this time other surgical approaches have been made of the brain and the spinal cord in the treatment of dyskinesias. In spite of the many thousands of procedures which have been performed, there are relatively few reports on the anatomical verification of the lesion site1-5 and correlation with the operative target, the short and long-term effects on the underlying neurological illness and the production of new symptoms by the lesions itself.5,6 The paucity of such data has hindered clinical rationale and treatment and has also inhibited physiological thought on tremor, rigidity, and other disordered patterns of movement.

The present work reviews the character and location of eight stereotaxic thalamic lesions in four cases of Parkinson's disease, and their modification of the