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December 1966

Radiation Necrosis and Repair in Rat Fetal Cerebral Hemisphere

Author Affiliations

From the departments of neurology, pathology, and anatomy, University of Utah College of Medicine, Salt Lake City.

Arch Neurol. 1966;15(6):615-628. doi:10.1001/archneur.1966.00470180055006

IN FETUSES exposed to 130 roentgens on the 13th day of gestation cellular necrosis in the cerebral vesicles is a consistent occurrence.1-3 Subsequently, reparative processes are evident,1 rosettes are formed, and malformations ensue.2-5 In this study the central nervous system (CNS) of fetuses was examined at intervals from ten minutes to six days following irradiation in utero, and the morphologic features of irradiation-induced cellular necrosis and repair are reported.

Materials and Methods  Pregnant female rats of the Sprague-Dawley strain were exposed to 130 R of whole body x-irradiation on the 13th day of gestation. The radiation was administered from the dorsal aspect with a 300-unit maxitron operated at 250 kilovolt (peak) (KVP) and 15 ma at the rate of 60 R/min. The calibration for appropriate dosage was made with an R meter, placed in a wax phantom at a depth corresponding to the depth of fetuses below

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