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This volume is a collection of papers and discussions presented at meetings sponsored by the National Institute of Neurological Diseases and Blindness in December 1964 dealing with the recent advances in animal virology, which have particular pertinence to the etiology and pathogenesis of subacute or chronic degenerative diseases of the nervous system. Included are sections on human neurological diseases suspected to be of viral etiology (kuru, amyotrophic lateral sclerosis, and multiple sclerosis), on studies of viruses responsible for neurological disease in man (rabies, rubella, herpes simplex, Vilyuisk and tick-borne encephalitis viruses), on the biological characteristics of several agents responsible for "slow" diseases of vertebrates (scrapie, visna, and Aleutian disease of mink), on chronic persistent infection of mice with lymphocytic choriomeningitis virus, and on latent infection with the oncogenic simian virus 40 and adenovirus type 12. Shorter sections on the immunology and on the genetics of subacute and chronic viral infections