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The literature concerned with infections complicating cranial surgery is sparse. This monograph briefly summarizes the experience of the Department of Neurological Surgery at the Massachusetts General Hospital over the period of years of socalled modern chemotherapy, and contrasts these statistics with others available in print. The relationships between factors such as type of operation, time expended, and surgical experience are brought into focus and discussed. Unfortunately, the subject is not one characterized by startlingly new insights or striking progress in efficacy of prophylaxis or treatment. However, as a basis for evaluating personal experience and comparing statistics, this compilation will serve a useful purpose.