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Article
February 1967

Serum Enzymes in Sex-Linked (Duchenne) Muscular Dystrophy

Author Affiliations

Detroit; Los Angeles; Charlottesville, Va
From the Department of Human Genetics, University of Michigan, Ann Arbor (Dr. Shaw); the Department of Medicine, University of California School for the Health Sciences, Los Angeles (Dr. Pearson and Dr. Chowdhury); and the Division of Neurology, University of Virginia School of Medicine, Charlottesville (Dr. Dreifuss). Dr. Shaw's present address is Department of Biology, Wayne State University, Detroit 48202.

Arch Neurol. 1967;16(2):115-122. doi:10.1001/archneur.1967.00470200003001
Abstract

IN MUSCULAR dystrophy, particularly of the Duchenne or sex-linked type, a number of enzymes generally have elevated levels in the serum. In diseases such as the various kinds of neurogenic muscular atrophy that may be mistaken for muscular dystrophy, enzyme levels are normal. On the other hand, diseases like hepatitis that may show high enzyme levels are readily distinguishable from muscular dystrophy by their symptoms. Thus, the serum enzymes are of great value in diagnosis whenever muscular dystrophy is a possibility. They are also very promising as a tool in research. The enzymes in the serum appear to enter the blood by leakage from damaged muscle cells. The determination of serum enzymes may provide a way of measuring the intensity of the disease process at a given time. If so, the enzymes are useful not only for diagnosis but are essential for studying the development of the disease and

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