THE PRODUCTION of abnormally discharging cortical foci in experimental animals provides a model having some resemblance to human focal epilepsy. Local cortical freezing is one of several procedures which have been effective in producing epileptogenic lesions. Nims et al employed an ethyl chloride spray to produce a freezing cortical lesion,1 and more recently Morrell et al have described in detail results with the same method.2 Although the rat has been said to be relatively resistant to cortical freezing,3 Morrell's technique has proved effective in inducing abnormally discharging lesions in this animal, and experience with the rat will be described.
Such lesions should be useful for investigating chemical alterations associated with the resulting electroencephalographic abnormality. The ATPase requiring Na+ and K+ as well as Mg++ for full activation (Na-K-ATPase) was selected for study because of the suggested association of this enzyme with transport of Na+ and K
Lewin E, McCrimmon A. ATPase Activity in Discharging Cortical Lesions Induced by Freezing. Arch Neurol. 1967;16(3):321–325. doi:10.1001/archneur.1967.00470210097010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.