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April 1967

Acute Hemodynamic Changes During Experimental Cerebral Embolism

Author Affiliations

Durham, NC
From the Center for Cerebrovascular Research and the Cardiovascular Laboratory, Duke University Medical Center, Durham, NC. Dr. Molinari is a trainee supported by the Vocational Rehabilitation Administration.

Arch Neurol. 1967;16(4):433-439. doi:10.1001/archneur.1967.00470220097011

THERE is little clinical information available in regard to the hemodynamic changes during the acute phase of cerebral embolism. In experimental animals profound alterations of blood pressure, heart rate, and respiration have been observed following cerebral embolization, but there is no agreement as to direction, magnitude, or mechanisms of these changes.1-4 Furthermore, the hemodynamic alterations observed in many of these studies have not been clearly separated from the effects of respiratory failure or carotid sinus stimulation produced by the experimental procedure.

The present study was designed to determine the degree and the duration of the hemodynamic alterations resulting from experimentally produced cerebral embolism and to study a possible means of preventing these manifestations.

Methods  Ten mongrel dogs weighing 12 to 14 kg (27 to 31 lb) were studied during anesthesia induced by intravenous injection of chloralose and urethane (48 and 480 mg/kg, respectively). Each animal was intubated and

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