Subsequentto the pioneer work of Seligman and Shear,1 gliomas have been successfully produced by the intracerebral implantation of chemical carcinogenic agents in experimental animals. Zimmerman and his co-workers have made extensive studies on the incidence of induced tumor and on the histogenetic origin and growth behavior or experimental brain tumors induced by methylchloranthrene, benzpyrene, dibenzenthracene, and dimethylbenzenthracene.2-6 The glioma produced in this fashion, however, may require a latent period of four months to two years before attaining substantial size, a relatively long period in the life span of mouse and rat.
It has been reported frequently that many kinds of embryonic tissue, including brain, when implanted into the animals of the same species, may not only survive but also may proliferate and differentiate rather rapidly in the host.7-11
In the last two decades oncologists have introduced the concept of "initiating" and "promoting" factors as two independent
Hosobuchi Y, Ishii S. A New Approach to Hydrocarbon-Induced Brain Tumors. Arch Neurol. 1967;16(6):664–675. doi:10.1001/archneur.1967.00470240102015
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