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This monograph reviews the problems of the distribution of water and electrolytes in the brain with specific reference to the problems of the size of the extracellular space in the brain. The author has made notable contributions to this field and was one of the early critics of the hypothesis that there was a lack of extracellular space in the brain based on electron microscopic studies. He has reviewed in some detail his own studies of impedance changes in the nervous system and has critically evaluated the literature regarding brain spaces. He concludes that there is an appreciable extracellular space in the brain filled with a fluid similar in composition to cerebrospinal fluid. Also, during asphyxiation and "spreading depression" there is a rapid transfer of extracellular fluid into the intracellular compartment.
There is little in the monograph of relevance to clinical practice, but it is a valuable contribution to the
Fishman RA. Brain Tissue Electrolytes. Arch Neurol. 1967;17(2):224. doi:10.1001/archneur.1967.00470260114020
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