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Article
September 1967

Steroids and Blood Brain Barrier Alterations in Sodium Acetrizoate Injury

Author Affiliations

St. Louis
From the Division of Neurosurgery, Department of Neurology, and the Beaumont-May Institute of Neurology, Washington University School of Medicine, St. Louis.

Arch Neurol. 1967;17(3):282-297. doi:10.1001/archneur.1967.00470270060008
Abstract

Steroids )TEROIDS have been widely used to ameliorate the effects of various kinds of cerebral injury. In experimentally induced injury some investigators indicate that steroids are beneficial,1-7 while others believe them to be without protective value.8-11 In cats with lengthy exposure of the brain to air, Prados1 attributed protection against swelling, electroencephalographic alterations, and increased capillary permeability (trypan blue) to the administration of extracts of anterior pituitary or of adrenal cortex. Grenell2 repeated the brain exposure experiments in a variety of species and concluded that adrenal cortical extracts prevented structural and functional changes in cerebral cortex.

Blinderman et al3 produced cerebral injury in dogs by the intracarotid injection of vegetable oil. Four of his eight animals treated with methylprednisolone sodium succinate (Solu-Medrol) developed no edema, two did develop it, and two showed equivocal results. The positive effects in the latter four could have been due

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