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December 1967

Effect of Brain Lesions on Striatal Monoamines in the Cat

Author Affiliations

From the Laboratory of Experimental Neuropsychiatry, Departments of physiology and pharmacology, Faculty of Medicine, Laval University, Quebec. Drs. Bouvier and Olivier are Fellows of the Medical Research Council of Canada; Dr. Larochelle is a grantee of a summer fellowship from the Medical Research Council of Canada.

Arch Neurol. 1967;17(6):601-608. doi:10.1001/archneur.1967.00470300043008

IN previous studies in the monkey, it was observed that there is a direct relationship betwen the interruption of ascending nervous fibers at the level of the ventromedial area of the upper brain stem, the retrograde cellular degeneration in the ipsilateral substantia nigra,1 and the depletion of dopamine in both parts of the homolateral striatum.2-4 Similarly, the depletion of serotonin in the striatum was attributed to the interruption of the most dorsomedial fibers of the cerebral peduncle on the corresponding side.5,6 These neuroanatomical and neurochemical changes are apparently important factors in the appearance of extrapyramidal signs and, more precisely, in the genesis of abnormal movements.2,4-6 Moreover, there is a close relationship between such results in the monkey and the findings previously reported in parkinsonian patients.7 In the light of our previous findings in the monkey,1-6 it was thought worthwhile to verify the results