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February 1968

Malfunction of Cerebral Microcirculation in Macroglobulinemic Mice: Relationship to Increased Blood Viscosity

Author Affiliations

Bethesda, Md
From Laboratory of Neuropathology, National Institute of Neurological Diseases and Blindness (Dr. Rosenblum); and Laboratory of Germfree Animal Research, National Institute of Allergy and Infectious Diseases (Dr. Asofsky), Bethesda, Md.

Arch Neurol. 1968;18(2):151-159. doi:10.1001/archneur.1968.00470320053006

THE natural history of human macroglobulinemia includes transient neurological symptoms ranging from headache to dizziness, dysequilibria, and focal motor weakness.1-3 In many cases these symptoms are associated with a rise in serum viscosity and are ameliorated by plasmaphoresis which reduces the concentration of macroglobulin (IgM) and the serum viscosity. These symptoms form a portion of the "hyperviscosity syndrome"1 and are often accompanied by "beading" or the presence of "box-car" deformities in retinal vessels.1,4-6 An experimental model of macroglobulinemia is provided by Balb/c mice, bearing a plasma cell tumor, (MOPC-104E), which secretes large amounts of IgM into the blood stream.7,8 Like their human counterparts1,9,10 these mice display an elevated blood viscosity which is a function of the concentration of IgM in the plasma, and which also depends upon the viscosity of the plasma, and the hematocrit level.8 Erythrocytes from these mice displayed a marked

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