IODINATED serum albumin (Risa) has been one of the most successful tracers for brain tumor detection.1-3 In previous studies some of the mechanisms involved in the uptake of radioactivity by human brain tumors and by a transplantable mouse ependymoblastoma after injection of iodinated serum albumin were established.4,5 It was shown that in the mouse glioma a large part of the radioactivity in the tumor was in the neoplastic cells and that almost all this radioactivity was protein bound. However, it was not established that the intact molecules of iodinated serum albumin entered neoplastic cells and were incorporated into tumor proteins. It is possible that iodinated serum albumin was metabolized in the interstitial fluid of the tumor or elsewhere in the body and that metabolic products of iodinated serum albumin were taken into tumor cells. Radioiodination of albumin is considered to take place mainly on the tyrosine residues,
Tator CH. Uptake of Radioiodinated Protein and Amino Acid by Mouse Glioma and Brain. Arch Neurol. 1968;18(2):202–207. doi:10.1001/archneur.1968.00470320104011
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