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March 1968

Concentration of Technectium 99m by the Choroid Plexus: Experimental Demonstration in Vivo

Author Affiliations

Winston-Salem, NC
From the departments of radiology and neurology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC. Dr. Maynard is a James Picker fellow in radiological research.

Arch Neurol. 1968;18(3):301-303. doi:10.1001/archneur.1968.00470330091009

IN AN earlier paper1 we described the apparent visualization of the choroid plexus on brain scans utilizing sodium pertechnetate Tc99m. Orally administered potassium perchlorate had been shown to block the active concentration of99mTc by the thyroid gland, stomach, and salivary glands.2-4 We found that 200 mg of potassium perchlorate administered one hour before brain scanning apparently blocked the accumulation of99mTc by the choroid plexus (Fig 1). Since perchlorate blocked this uptake, we reasoned that the observations presented convincing, inferential evidence of an active concentration process for99mTc by the choroid plexus. We have performed experiments on rabbits in an attempt to evaluate the hypotheses that the choroid plexus actively concentrates the pertechnetate ion above blood levels and that this accumulation can be blocked by perchlorate.

Materials and Methods  Eighteen rabbits weighing between 1.8 and 2.2 kg (4 and 5 lb) were

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