NEOPLASMS have been shown to have different metabolic characteristics than normal tissues. Warburg1 observed a greater tendency to derive energy from anaerobic glycolysis with the production of increased amounts of lactic acid. He later suggested that an early step in the development of a neoplasm was a disturbance in cellular respiratory activity.2 Heller and Elliott showed that the rate of glycolysis was higher in human brain tumors than in normal gray matter when considered in relation to their respiratory rate.3 Hill and Levi4 noted that lactic dehydrogenase (LDH), the enzyme at the end of the metabolic chain of anaerobic glycolysis, was elevated in the serum of some patients with neoplastic disease. Increased amount of lactate and LDH have been found in brain tumor homogenates.5
In recent years it has been shown that the LDH activity of serum or tissue extracts is not
Sherwin AL, LeBlanc FE, McCann WP. Altered LDH Isozymes in Brain Tumors. Arch Neurol. 1968;18(3):311–315. doi:10.1001/archneur.1968.00470330101011
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.