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April 1968

Guillain-Barré-Strohl Syndrome

Arch Neurol. 1968;18(4):449. doi:10.1001/archneur.1968.00470340135013

IN the midst of World War I, Georges Guillain, J. A. Barré, and A. Strohl made an important contribution to neurology by reporting an illness in two French soldiers. The significance of their observation did not lie in the description of a new disease. Landry,1 in 1859, had reported a similar condition, characterized by acute ascending paralysis, which was mainly motor and which usually led to complete recovery. Following this original description, Landry's paralysis had become a well-known clinical entity. The contribution of Guillain, Barré, and Strohl was made possible by Quincke's introduction of the technique of lumbar puncture in 18912 and consisted in the observation of increased protein in the spinal fluid without cellular reaction. The pathologic identification of the disease as a radiculopathy was not made by Landry, who observed no abnormality in the nervous system at autopsy, nor by Guillain, Barré, and Strohl, who