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June 1968

Adie's Syndrome

Author Affiliations

Durham, NC
From the Divisions of Neurology and Neurosurgery, Duke University Medical Center, Durham, NC.

Arch Neurol. 1968;18(6):710-715. doi:10.1001/archneur.1968.00470360132015

MEDICAL men have seldom been shy in claiming paternity for orphaned syndromes and bestowing their names on them. William Adie's description of the tonic pupil with absent tendon reflexes is partly a dialectic to establish his priority. It is also an attempt to broaden the syndrome by defining incomplete forms. Although Adie's priority is dubious (see the review by Lowenstein and Loewenfeld1) and his inclusion of absent tendon reflexes sine tonic pupil as an abortive form has not been generally accepted, nevertheless the enthusiasm he brought to the subject has made his paper a classic. He succeeded in directing medical attention toward a pupillary abnormality often mistaken as a sign of a more serious disease.

The syndrome has stood substantially as described by Adie (1886-1935), who was an Australian neurologist working in England.

The only significant advance has been the pharmacologic study of Scheie,2 which provided the clinically

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